diff --git a/src/libslic3r/AppConfig.cpp b/src/libslic3r/AppConfig.cpp
index 41c140359b..bca966900a 100644
--- a/src/libslic3r/AppConfig.cpp
+++ b/src/libslic3r/AppConfig.cpp
@@ -698,7 +698,7 @@ std::string AppConfig::load()
     auto it_app = m_storage.find("app");
     if (it_app != m_storage.end()) {
         auto it_region = it_app->second.find("region");
-        if (it_region != it_app->second.end() && it_region->second == "China") {
+        if (it_region != it_app->second.end() && (it_region->second == "China" || it_region->second == "")) {
             it_region->second = "Chinese Mainland";
             m_dirty = true;
         }
diff --git a/src/slic3r/GUI/SSWCP.cpp b/src/slic3r/GUI/SSWCP.cpp
index 239047f7dc..037e9912aa 100644
--- a/src/slic3r/GUI/SSWCP.cpp
+++ b/src/slic3r/GUI/SSWCP.cpp
@@ -28,6 +28,7 @@
 #include "MoonRaker.hpp"
 
 #include "slic3r/GUI/WebPresetDialog.hpp"
+#include <mutex>
 
 #include "slic3r/GUI/SMPhysicalPrinterDialog.hpp"
 #include "slic3r/GUI/WebUrlDialog.hpp"
@@ -184,6 +185,7 @@ WCP_Logger::~WCP_Logger()
 }
 
 extern json m_ProfileJson;
+extern std::mutex m_ProfileJson_mutex;
 
 std::vector<std::string> load_thumbnails(const std::string& file, size_t image_count)
 {
@@ -5236,30 +5238,33 @@ void SSWCP_MqttAgent_Instance::sw_mqtt_set_engine()
                                             m_dialog->m_device_id = ip;
 
                                             // 检查是否该预设已经选入系统
-                                            int  nModel = m_ProfileJson["model"].size();
-                                            bool isFind = false;
-                                            for (int m = 0; m < nModel; m++) {
-                                                if (m_ProfileJson["model"][m]["model"].get<std::string>() == info.model_name) {
-                                                    // 绑定的预设已被选入系统
-                                                    isFind                      = true;
-                                                    std::string nozzle_selected = m_ProfileJson["model"][m]["nozzle_selected"]
-                                                                                      .get<std::string>();
-                                                    std::string se_nozz_selected = nozzle_diameters[0];
-                                                    if (nozzle_selected.find(se_nozz_selected) == std::string::npos) {
-                                                        nozzle_selected += ";" + se_nozz_selected;
-                                                        m_ProfileJson["model"][m]["nozzle_selected"] = nozzle_selected;
+                                            {
+                                                std::lock_guard<std::mutex> lock(m_ProfileJson_mutex);
+                                                int  nModel = m_ProfileJson["model"].size();
+                                                bool isFind = false;
+                                                for (int m = 0; m < nModel; m++) {
+                                                    if (m_ProfileJson["model"][m]["model"].get<std::string>() == info.model_name) {
+                                                        // 绑定的预设已被选入系统
+                                                        isFind                      = true;
+                                                        std::string nozzle_selected = m_ProfileJson["model"][m]["nozzle_selected"]
+                                                                                              .get<std::string>();
+                                                        std::string se_nozz_selected = nozzle_diameters[0];
+                                                        if (nozzle_selected.find(se_nozz_selected) == std::string::npos) {
+                                                            nozzle_selected += ";" + se_nozz_selected;
+                                                            m_ProfileJson["model"][m]["nozzle_selected"] = nozzle_selected;
+                                                        }
+
+                                                        break;
                                                     }
-
-                                                    break;
                                                 }
-                                            }
 
-                                            if (!isFind) {
-                                                json new_item;
-                                                new_item["vendor"]          = "Snapmaker";
-                                                new_item["model"]           = info.model_name;
-                                                new_item["nozzle_selected"] = nozzle_diameters[0];
-                                                m_ProfileJson["model"].push_back(new_item);
+                                                if (!isFind) {
+                                                    json new_item;
+                                                    new_item["vendor"]          = "Snapmaker";
+                                                    new_item["model"]           = info.model_name;
+                                                    new_item["nozzle_selected"] = nozzle_diameters[0];
+                                                    m_ProfileJson["model"].push_back(new_item);
+                                                }
                                             }
 
                                             wxGetApp().mainframe->plater()->sidebar().update_all_preset_comboboxes(false);
diff --git a/src/slic3r/GUI/WebGuideDialog.cpp b/src/slic3r/GUI/WebGuideDialog.cpp
index 483508bdef..7620b34bf2 100644
--- a/src/slic3r/GUI/WebGuideDialog.cpp
+++ b/src/slic3r/GUI/WebGuideDialog.cpp
@@ -33,12 +33,14 @@
 #include <libslic3r/miniz_extension.hpp>
 #include <libslic3r/Utils.hpp>
 #include "CreatePresetsDialog.hpp"
+#include <mutex>
 
 using namespace nlohmann;
 
 namespace Slic3r { namespace GUI {
 
 json m_ProfileJson;
+std::mutex m_ProfileJson_mutex;
 
 static wxString update_custom_filaments()
 {
@@ -229,7 +231,11 @@ wxString GuideFrame::SetStartPage(GuidePage startpage, bool load)
     } else if (startpage == BBL_FILAMENTS) {
         SetTitle(_L("Setup Wizard"));
 
-        int nSize = m_ProfileJson["model"].size();
+        int nSize;
+        {
+            std::lock_guard<std::mutex> lock(m_ProfileJson_mutex);
+            nSize = m_ProfileJson["model"].size();
+        }
 
         if (nSize>0)
             TargetUrl = from_u8((boost::filesystem::path(resources_dir()) / "web/guide/0/index.html?target=22").make_preferred().string());
@@ -403,7 +409,10 @@ void GuideFrame::OnScriptMessage(wxWebViewEvent &evt)
             json m_Res = json::object();
             m_Res["command"] = "response_userguide_profile";
             m_Res["sequence_id"] = "10001";
-            m_Res["response"]        = m_ProfileJson;
+            {
+                std::lock_guard<std::mutex> lock(m_ProfileJson_mutex);
+                m_Res["response"] = m_ProfileJson;
+            }
 
             //wxString strJS = wxString::Format("HandleStudio(%s)", m_Res.dump(-1, ' ', false, json::error_handler_t::ignore));
             wxString strJS = wxString::Format("HandleStudio(%s)", m_Res.dump(-1, ' ', true));
@@ -426,43 +435,53 @@ void GuideFrame::OnScriptMessage(wxWebViewEvent &evt)
         {
             json MSelected = j["data"];
 
-            int nModel = m_ProfileJson["model"].size();
-            for (int m = 0; m < nModel; m++) {
-                json TmpModel = m_ProfileJson["model"][m];
-                m_ProfileJson["model"][m]["nozzle_selected"] = "";
+            {
+                std::lock_guard<std::mutex> lock(m_ProfileJson_mutex);
+                int nModel = m_ProfileJson["model"].size();
+                for (int m = 0; m < nModel; m++) {
+                    json TmpModel = m_ProfileJson["model"][m];
+                    m_ProfileJson["model"][m]["nozzle_selected"] = "";
 
-                for (auto it = MSelected.begin(); it != MSelected.end(); ++it) {
-                    json OneSelect = it.value();
+                    for (auto it = MSelected.begin(); it != MSelected.end(); ++it) {
+                        json OneSelect = it.value();
 
-                    wxString s1 = TmpModel["model"];
-                    wxString s2 = OneSelect["model"];
-                    if (s1.compare(s2) == 0) {
-                        m_ProfileJson["model"][m]["nozzle_selected"] = OneSelect["nozzle_diameter"];
-                        break;
+                        wxString s1 = TmpModel["model"];
+                        wxString s2 = OneSelect["model"];
+                        if (s1.compare(s2) == 0) {
+                            m_ProfileJson["model"][m]["nozzle_selected"] = OneSelect["nozzle_diameter"];
+                            break;
+                        }
                     }
                 }
             }
         }
         else if (strCmd == "save_userguide_filaments") {
-            //reset
-            for (auto it = m_ProfileJson["filament"].begin(); it != m_ProfileJson["filament"].end(); ++it)
             {
-                m_ProfileJson["filament"][it.key()]["selected"] = 0;
-            }
+                std::lock_guard<std::mutex> lock(m_ProfileJson_mutex);
+                //reset
+                for (auto it = m_ProfileJson["filament"].begin(); it != m_ProfileJson["filament"].end(); ++it)
+                {
+                    m_ProfileJson["filament"][it.key()]["selected"] = 0;
+                }
 
-            json fSelected = j["data"]["filament"];
-            int nF = fSelected.size();
-            for (int m = 0; m < nF; m++)
-            {
-                std::string fName = fSelected[m];
+                json fSelected = j["data"]["filament"];
+                int nF = fSelected.size();
+                for (int m = 0; m < nF; m++)
+                {
+                    std::string fName = fSelected[m];
 
-                m_ProfileJson["filament"][fName]["selected"] = 1;
+                    m_ProfileJson["filament"][fName]["selected"] = 1;
+                }
             }
         }
         else if (strCmd == "user_guide_finish") {
             SaveProfile();
 
-            std::string oldregion = m_ProfileJson["region"];
+            std::string oldregion;
+            {
+                std::lock_guard<std::mutex> lock(m_ProfileJson_mutex);
+                oldregion = m_ProfileJson["region"];
+            }
             bool        bLogin    = false;
             if (m_Region != oldregion) {
                 AppConfig* config = GUI::wxGetApp().app_config;
@@ -492,7 +511,10 @@ void GuideFrame::OnScriptMessage(wxWebViewEvent &evt)
             this->Close();
         } else if (strCmd == "save_region") {
             m_Region = j["region"];
-            m_ProfileJson["region"] = m_Region;
+            {
+                std::lock_guard<std::mutex> lock(m_ProfileJson_mutex);
+                m_ProfileJson["region"] = m_Region;
+            }
         }
         else if (strCmd == "common_openurl") {
             
@@ -635,7 +657,11 @@ int GuideFrame::SaveProfile()
 
     m_MainPtr->app_config->save();
 
-    std::string strAll = m_ProfileJson.dump(-1, ' ', false, json::error_handler_t::ignore);
+    std::string strAll;
+    {
+        std::lock_guard<std::mutex> lock(m_ProfileJson_mutex);
+        strAll = m_ProfileJson.dump(-1, ' ', false, json::error_handler_t::ignore);
+    }
 
     BOOST_LOG_TRIVIAL(info) << __FUNCTION__ << "before save to app_config: "<< std::endl<<strAll;
 
@@ -643,9 +669,12 @@ int GuideFrame::SaveProfile()
     const std::string &section_name = AppConfig::SECTION_FILAMENTS;
     std::map<std::string, std::string> section_new;
     m_appconfig_new.clear_section(section_name);
-    for (auto it = m_ProfileJson["filament"].begin(); it != m_ProfileJson["filament"].end(); ++it) {
-        if (it.value()["selected"] == 1){
-            section_new[it.key()] = "true";
+    {
+        std::lock_guard<std::mutex> lock(m_ProfileJson_mutex);
+        for (auto it = m_ProfileJson["filament"].begin(); it != m_ProfileJson["filament"].end(); ++it) {
+            if (it.value()["selected"] == 1){
+                section_new[it.key()] = "true";
+            }
         }
     }
     m_appconfig_new.set_section(section_name, section_new);
@@ -653,7 +682,9 @@ int GuideFrame::SaveProfile()
     //set vendors to app_config
     Slic3r::AppConfig::VendorMap empty_vendor_map;
     m_appconfig_new.set_vendors(empty_vendor_map);
-    for (auto it = m_ProfileJson["model"].begin(); it != m_ProfileJson["model"].end(); ++it)
+    {
+        std::lock_guard<std::mutex> lock(m_ProfileJson_mutex);
+        for (auto it = m_ProfileJson["model"].begin(); it != m_ProfileJson["model"].end(); ++it)
     {
         if (it.value().is_object()) {
             json temp_model = it.value();
@@ -997,6 +1028,7 @@ int GuideFrame::GetFilamentInfo( std::string VendorDirectory, json & pFilaList,
 
 int GuideFrame::LoadProfileData()
 {
+    std::lock_guard<std::mutex> lock(m_ProfileJson_mutex);
     try {
         m_ProfileJson             = json::parse("{}");
         m_ProfileJson["model"]    = json::array();
@@ -1068,7 +1100,7 @@ int GuideFrame::LoadProfileData()
         }
 
         //sync to web
-        std::string strAll = m_ProfileJson.dump(-1, ' ', false, json::error_handler_t::ignore);
+        std::string strAll = m_ProfileJson.dump(-1, ' ', false, json::error_handler_t::ignore);  // Already locked at function start
 
         BOOST_LOG_TRIVIAL(info) << __FUNCTION__ << ", finished, json contents: " << std::endl << strAll;
         json m_Res           = json::object();
@@ -1093,6 +1125,7 @@ int GuideFrame::LoadProfileData()
 
 int GuideFrame::SaveProfileData()
 {
+    std::lock_guard<std::mutex> lock(m_ProfileJson_mutex);
     try {
         const auto enabled_filaments = wxGetApp().app_config->has_section(AppConfig::SECTION_FILAMENTS) ? wxGetApp().app_config->get_section(AppConfig::SECTION_FILAMENTS) : std::map<std::string, std::string>();
         m_appconfig_new.set_vendors(*wxGetApp().app_config);
diff --git a/src/slic3r/GUI/WebPresetDialog.cpp b/src/slic3r/GUI/WebPresetDialog.cpp
index 95853e3cad..841d06d3c5 100644
--- a/src/slic3r/GUI/WebPresetDialog.cpp
+++ b/src/slic3r/GUI/WebPresetDialog.cpp
@@ -30,12 +30,14 @@
 #include <libslic3r/Utils.hpp>
 #include "CreatePresetsDialog.hpp"
 #include "slic3r/GUI/Tab.hpp"
+#include <mutex>
 
 using namespace nlohmann;
 
 namespace Slic3r { namespace GUI {
 
 extern json m_ProfileJson;
+extern std::mutex m_ProfileJson_mutex;
 extern void StringReplace(string& strBase, string strSrc, string strDes);
 
 static wxString update_custom_filaments()
@@ -112,7 +114,7 @@ static wxString update_custom_filaments()
 }
 
 WebPresetDialog::WebPresetDialog(GUI_App* pGUI, long style)
-    : DPIDialog((wxWindow*) (pGUI->mainframe), wxID_ANY, "Snapmaker Orca", wxDefaultPosition, wxDefaultSize, style), m_appconfig_new()
+    : DPIDialog((wxWindow*) (nullptr), wxID_ANY, "Snapmaker Orca", wxDefaultPosition, wxDefaultSize, style), m_appconfig_new()
 {
     SetBackgroundColour(*wxWHITE);
     // INI
@@ -424,7 +426,11 @@ void WebPresetDialog::OnScriptMessage(wxWebViewEvent& evt)
             m_Res["command"]     = "response_userguide_profile";
             m_Res["sequence_id"] = "10001";
 
-            json res_json = m_ProfileJson;
+            json res_json;
+            {
+                std::lock_guard<std::mutex> lock(m_ProfileJson_mutex);
+                res_json = m_ProfileJson;
+            }
 
             // 把所有的选中信息取消，换成当前连接的机器
             std::string model_name = "";
@@ -491,27 +497,30 @@ void WebPresetDialog::OnScriptMessage(wxWebViewEvent& evt)
         } else if (strCmd == "save_userguide_models") {
             json MSelected = j["data"];
 
-            int nModel = m_ProfileJson["model"].size();
-            bool isFind = false;
-            for (int m = 0; m < nModel; m++) {
-                if (m_ProfileJson["model"][m]["model"].get<std::string>() == MSelected.begin().value()["model"].get<std::string>()) {
-                    // 绑定的预设已被选入系统
-                    isFind = true;
-                    std::string nozzle_selected = m_ProfileJson["model"][m]["nozzle_selected"].get<std::string>();
-                    std::string se_nozz_selected = MSelected.begin().value()["nozzle_diameter"].get<std::string>();
-                    if (nozzle_selected.find(se_nozz_selected) == std::string::npos) {
-                        nozzle_selected += ";" + se_nozz_selected;
-                        m_ProfileJson["model"][m]["nozzle_selected"] = nozzle_selected;
-                    }
+            {
+                std::lock_guard<std::mutex> lock(m_ProfileJson_mutex);
+                int nModel = m_ProfileJson["model"].size();
+                bool isFind = false;
+                for (int m = 0; m < nModel; m++) {
+                    if (m_ProfileJson["model"][m]["model"].get<std::string>() == MSelected.begin().value()["model"].get<std::string>()) {
+                        // 绑定的预设已被选入系统
+                        isFind = true;
+                        std::string nozzle_selected = m_ProfileJson["model"][m]["nozzle_selected"].get<std::string>();
+                        std::string se_nozz_selected = MSelected.begin().value()["nozzle_diameter"].get<std::string>();
+                        if (nozzle_selected.find(se_nozz_selected) == std::string::npos) {
+                            nozzle_selected += ";" + se_nozz_selected;
+                            m_ProfileJson["model"][m]["nozzle_selected"] = nozzle_selected;
+                        }
 
-                    break;
+                        break;
+                    }
+                }
+                if (!isFind) {
+                    json new_item;
+                    new_item["model"] = MSelected.begin().value()["model"];
+                    new_item["nozzle_selected"] = MSelected.begin().value()["nozzle_diameter"];
+                    m_ProfileJson["model"].push_back(new_item);
                 }
-            }
-            if (!isFind) {
-                json new_item;
-                new_item["model"] = MSelected.begin().value()["model"];
-                new_item["nozzle_selected"] = MSelected.begin().value()["nozzle_diameter"];
-                m_ProfileJson["model"].push_back(new_item);
             }
 
             DeviceInfo info;
@@ -548,22 +557,29 @@ void WebPresetDialog::OnScriptMessage(wxWebViewEvent& evt)
             }
 
         } else if (strCmd == "save_userguide_filaments") {
-            // reset
-            for (auto it = m_ProfileJson["filament"].begin(); it != m_ProfileJson["filament"].end(); ++it) {
-                m_ProfileJson["filament"][it.key()]["selected"] = 0;
-            }
+            {
+                std::lock_guard<std::mutex> lock(m_ProfileJson_mutex);
+                // reset
+                for (auto it = m_ProfileJson["filament"].begin(); it != m_ProfileJson["filament"].end(); ++it) {
+                    m_ProfileJson["filament"][it.key()]["selected"] = 0;
+                }
 
-            json fSelected = j["data"]["filament"];
-            int  nF        = fSelected.size();
-            for (int m = 0; m < nF; m++) {
-                std::string fName = fSelected[m];
+                json fSelected = j["data"]["filament"];
+                int  nF        = fSelected.size();
+                for (int m = 0; m < nF; m++) {
+                    std::string fName = fSelected[m];
 
-                m_ProfileJson["filament"][fName]["selected"] = 1;
+                    m_ProfileJson["filament"][fName]["selected"] = 1;
+                }
             }
         } else if (strCmd == "user_guide_finish") {
             SaveProfile();
 
-            std::string oldregion = m_ProfileJson["region"];
+            std::string oldregion;
+            {
+                std::lock_guard<std::mutex> lock(m_ProfileJson_mutex);
+                oldregion = m_ProfileJson["region"];
+            }
             bool        bLogin    = false;
             if (m_Region != oldregion) {
                 AppConfig*    config       = GUI::wxGetApp().app_config;
@@ -590,7 +606,10 @@ void WebPresetDialog::OnScriptMessage(wxWebViewEvent& evt)
             this->Close();
         } else if (strCmd == "save_region") {
             m_Region = j["region"];
-            m_ProfileJson["region"] = m_Region;
+            {
+                std::lock_guard<std::mutex> lock(m_ProfileJson_mutex);
+                m_ProfileJson["region"] = m_Region;
+            }
         }
         else if (strCmd == "common_openurl") {
            
@@ -622,7 +641,10 @@ void WebPresetDialog::OnScriptMessage(wxWebViewEvent& evt)
         BOOST_LOG_TRIVIAL(trace) << "WebPresetDialog::OnScriptMessage;Error:" << e.what();
     }
 
-    wxString strAll = m_ProfileJson.dump(-1, ' ', false, json::error_handler_t::ignore);
+    {
+        std::lock_guard<std::mutex> lock(m_ProfileJson_mutex);
+        wxString strAll = m_ProfileJson.dump(-1, ' ', false, json::error_handler_t::ignore);
+    }
 }
 
 void WebPresetDialog::RunScript(const wxString& javascript)
@@ -754,7 +776,11 @@ int WebPresetDialog::SaveProfile()
 
     m_MainPtr->app_config->save();
 
-    std::string strAll = m_ProfileJson.dump(-1, ' ', false, json::error_handler_t::ignore);
+    std::string strAll;
+    {
+        std::lock_guard<std::mutex> lock(m_ProfileJson_mutex);
+        strAll = m_ProfileJson.dump(-1, ' ', false, json::error_handler_t::ignore);
+    }
 
     BOOST_LOG_TRIVIAL(info) << __FUNCTION__ << "before save to app_config: " << std::endl << strAll;
 
@@ -762,9 +788,12 @@ int WebPresetDialog::SaveProfile()
     const std::string&                 section_name = AppConfig::SECTION_FILAMENTS;
     std::map<std::string, std::string> section_new;
     m_appconfig_new.clear_section(section_name);
-    for (auto it = m_ProfileJson["filament"].begin(); it != m_ProfileJson["filament"].end(); ++it) {
-        if (it.value()["selected"] == 1) {
-            section_new[it.key()] = "true";
+    {
+        std::lock_guard<std::mutex> lock(m_ProfileJson_mutex);
+        for (auto it = m_ProfileJson["filament"].begin(); it != m_ProfileJson["filament"].end(); ++it) {
+            if (it.value()["selected"] == 1) {
+                section_new[it.key()] = "true";
+            }
         }
     }
     m_appconfig_new.set_section(section_name, section_new);
@@ -772,7 +801,9 @@ int WebPresetDialog::SaveProfile()
     // set vendors to app_config
     Slic3r::AppConfig::VendorMap empty_vendor_map;
     m_appconfig_new.set_vendors(empty_vendor_map);
-    for (auto it = m_ProfileJson["model"].begin(); it != m_ProfileJson["model"].end(); ++it) {
+    {
+        std::lock_guard<std::mutex> lock(m_ProfileJson_mutex);
+        for (auto it = m_ProfileJson["model"].begin(); it != m_ProfileJson["model"].end(); ++it) {
         if (it.value().is_object()) {
             json        temp_model  = it.value();
             std::string model_name  = temp_model["model"];
@@ -1121,6 +1152,7 @@ int WebPresetDialog::GetFilamentInfo(std::string VendorDirectory, json& pFilaLis
 
 int WebPresetDialog::LoadProfile()
 {
+    std::lock_guard<std::mutex> lock(m_ProfileJson_mutex);
     try {
         // wxString ExePath            = boost::dll::program_location().parent_path().string();
         // wxString TargetFolder       = ExePath + "\\resources\\profiles\\";