diff --git a/src/slic3r/GUI/MainFrame.cpp b/src/slic3r/GUI/MainFrame.cpp
index 9566426c53..5dc1f0ccfc 100644
--- a/src/slic3r/GUI/MainFrame.cpp
+++ b/src/slic3r/GUI/MainFrame.cpp
@@ -1110,6 +1110,8 @@ void MainFrame::update_edge_panels()
 void MainFrame::shutdown()
 {
     BOOST_LOG_TRIVIAL(info) << __FUNCTION__ << "MainFrame::shutdown enter";
+    if (m_project != nullptr)
+        m_project->shutdown();
     m_plugin_pages.shutdown();
 #ifdef __WXGTK__
     // Edge panels are child windows — wxWidgets destroys them automatically.
diff --git a/src/slic3r/GUI/Project.cpp b/src/slic3r/GUI/Project.cpp
index 57410b1202..6d1eb0e180 100644
--- a/src/slic3r/GUI/Project.cpp
+++ b/src/slic3r/GUI/Project.cpp
@@ -74,7 +74,18 @@ ProjectPanel::ProjectPanel(wxWindow *parent, wxWindowID id, const wxPoint &pos,
     Fit();
 }
 
-ProjectPanel::~ProjectPanel() {}
+ProjectPanel::~ProjectPanel()
+{
+    shutdown();
+}
+
+void ProjectPanel::shutdown()
+{
+    m_reload_cancel_token->store(true, std::memory_order_release);
+    if (m_reload_task && m_reload_task->joinable())
+        m_reload_task->join();
+    m_reload_task.reset();
+}
 
 // Helper to convert newlines to <br>
 static std::string convert_newlines_to_br(const std::string& text) {
@@ -101,7 +112,17 @@ void ProjectPanel::onWebNavigating(wxWebViewEvent& evt)
 
 void ProjectPanel::on_reload(wxCommandEvent& evt)
 {
-    boost::thread reload = boost::thread([this] {
+    if (wxTheApp == nullptr || wxGetApp().is_closing() ||
+        m_reload_cancel_token->load(std::memory_order_acquire))
+        return;
+
+    if (m_reload_task && m_reload_task->joinable())
+        m_reload_task->join();
+
+    const auto cancel_token = m_reload_cancel_token;
+    m_reload_task = std::make_unique<boost::thread>([this, cancel_token] {
+        if (cancel_token->load(std::memory_order_acquire) || wxTheApp == nullptr || wxGetApp().is_closing())
+            return;
         std::string update_type;
         std::string license;
         std::string model_name;
@@ -115,6 +136,9 @@ void ProjectPanel::on_reload(wxCommandEvent& evt)
 
         std::map<std::string, std::vector<json>> files;
 
+        if (wxGetApp().plater() == nullptr)
+            return;
+
         Model model = wxGetApp().plater()->model();
 
         auto model_info = model.model_info;
@@ -156,7 +180,14 @@ void ProjectPanel::on_reload(wxCommandEvent& evt)
         std::string file_path = encode_path(wxGetApp().plater()->model().get_auxiliary_file_temp_path().c_str());
         if (!file_path.empty()) {
             files = Reload(file_path);
-            wxGetApp().CallAfter([this, file_path, files] { m_auxiliary->Reload(file_path, files); });
+            if (cancel_token->load(std::memory_order_acquire) || wxTheApp == nullptr || wxGetApp().is_closing())
+                return;
+
+            wxGetApp().CallAfter([this, cancel_token, file_path, files] {
+                if (cancel_token->load(std::memory_order_acquire) || wxTheApp == nullptr || wxGetApp().is_closing())
+                    return;
+                m_auxiliary->Reload(file_path, files);
+            });
         } else {
             clear_model_info();
             return;
@@ -215,15 +246,18 @@ void ProjectPanel::on_reload(wxCommandEvent& evt)
 
         json m_Res = json::object();
         m_Res["command"] = "show_3mf_info";
-        m_Res["sequence_id"] = std::to_string(ProjectPanel::m_sequence_id++);
+        m_Res["sequence_id"] = std::to_string(ProjectPanel::m_sequence_id.fetch_add(1, std::memory_order_relaxed));
         m_Res["model"] = j;
 
         wxString strJS = wxString::Format("HandleStudio(%s)", m_Res.dump(-1, ' ', false, json::error_handler_t::ignore));
 
-        if (m_web_init_completed) {
-            wxGetApp().CallAfter([this, strJS] {
+        if (m_web_init_completed.load(std::memory_order_acquire) &&
+            !cancel_token->load(std::memory_order_acquire) && wxTheApp != nullptr && !wxGetApp().is_closing()) {
+            wxGetApp().CallAfter([this, cancel_token, strJS] {
+                if (cancel_token->load(std::memory_order_acquire) || wxTheApp == nullptr || wxGetApp().is_closing())
+                    return;
                 RunScript(strJS.ToStdString());
-                });
+            });
         }
     });
 }
@@ -264,7 +298,7 @@ void ProjectPanel::OnScriptMessage(wxWebViewEvent& evt)
             }
         }
         else if (strCmd == "request_3mf_info") {
-            m_web_init_completed = true;
+            m_web_init_completed.store(true, std::memory_order_release);
         }
         else if (strCmd == "edit_project_info") {
             show_info_editor(true);
@@ -307,13 +341,20 @@ void ProjectPanel::update_model_data()
 
 void ProjectPanel::clear_model_info()
 {
+    if (wxTheApp == nullptr || wxGetApp().is_closing() ||
+        m_reload_cancel_token->load(std::memory_order_acquire))
+        return;
+
     json m_Res = json::object();
     m_Res["command"] = "clear_3mf_info";
-    m_Res["sequence_id"] = std::to_string(ProjectPanel::m_sequence_id++);
+    m_Res["sequence_id"] = std::to_string(ProjectPanel::m_sequence_id.fetch_add(1, std::memory_order_relaxed));
 
     wxString strJS = wxString::Format("HandleStudio(%s)", m_Res.dump(-1, ' ', false, json::error_handler_t::ignore));
 
-    wxGetApp().CallAfter([this, strJS] {
+    const auto cancel_token = m_reload_cancel_token;
+    wxGetApp().CallAfter([this, cancel_token, strJS] {
+        if (cancel_token->load(std::memory_order_acquire) || wxTheApp == nullptr || wxGetApp().is_closing())
+            return;
         RunScript(strJS.ToStdString());
     });
 }
diff --git a/src/slic3r/GUI/Project.hpp b/src/slic3r/GUI/Project.hpp
index 0071685e7d..a41f76ba7e 100644
--- a/src/slic3r/GUI/Project.hpp
+++ b/src/slic3r/GUI/Project.hpp
@@ -26,9 +26,11 @@
 #include "nlohmann/json.hpp"
 #include "slic3r/Utils/json_diff.hpp"
 
+#include <atomic>
 #include <map>
 #include <vector>
 #include <memory>
+#include <boost/thread.hpp>
 #include "Event.hpp"
 #include "libslic3r/ProjectTask.hpp"
 #include "wxExtensions.hpp"
@@ -60,14 +62,17 @@ struct project_file{
 class ProjectPanel : public wxPanel
 {
 private:
-    bool       m_web_init_completed = {false};
+    std::atomic<bool> m_web_init_completed{false};
     bool       m_reload_already = {false};
 
+    std::shared_ptr<std::atomic<bool>> m_reload_cancel_token{std::make_shared<std::atomic<bool>>(false)};
+    std::unique_ptr<boost::thread> m_reload_task;
+
     wxWebView* m_browser = {nullptr};
     AuxiliaryPanel*   m_auxiliary{nullptr};
     wxString   m_project_home_url;
     wxString   m_root_dir;
-    static inline int m_sequence_id = 8000;
+    static inline std::atomic<int> m_sequence_id{8000};
 
     void show_info_editor(bool show);
     
@@ -75,6 +80,7 @@ private:
 public:
     ProjectPanel(wxWindow *parent, wxWindowID id = wxID_ANY, const wxPoint &pos = wxDefaultPosition, const wxSize &size = wxDefaultSize, long style = wxTAB_TRAVERSAL);
     ~ProjectPanel();
+    void shutdown();
 
     
     void onWebNavigating(wxWebViewEvent& evt);
diff --git a/src/slic3r/GUI/Tab.cpp b/src/slic3r/GUI/Tab.cpp
index 05631c8afa..469864af46 100644
--- a/src/slic3r/GUI/Tab.cpp
+++ b/src/slic3r/GUI/Tab.cpp
@@ -8477,8 +8477,12 @@ void Page::activate(ConfigOptionMode mode, std::function<void()> throw_if_cancel
 
 #ifdef __WXMSW__
     // BBS: fix field control position
-    wxTheApp->CallAfter([this]() {
-        for (auto group : m_optgroups) {
+    wxTheApp->CallAfter([wp = std::weak_ptr<Page>(shared_from_this())]() {
+        auto page = wp.lock();
+        if (!page)
+            return;
+
+        for (auto group : page->m_optgroups) {
             if (group->custom_ctrl)
                 group->custom_ctrl->fixup_items_positions();
         }