diff --git a/src/slic3r/GUI/GLCanvas3D.cpp b/src/slic3r/GUI/GLCanvas3D.cpp
index ab034168b6..e25cf41511 100644
--- a/src/slic3r/GUI/GLCanvas3D.cpp
+++ b/src/slic3r/GUI/GLCanvas3D.cpp
@@ -79,6 +79,13 @@
 
 #include <imguizmo/ImGuizmo.h>
 
+#ifdef __WXMSW__
+#if wxUSE_POPUPWIN
+#include <wx/popupwin.h>
+extern wxPopupWindow* wxCurrentPopupWindow;
+#endif
+#endif
+
 static constexpr const float TRACKBALLSIZE = 0.8f;
 
 static Slic3r::ColorRGBA DEFAULT_BG_LIGHT_COLOR      = { 0.906f, 0.906f, 0.906f, 1.0f };
@@ -4258,14 +4265,21 @@ void GLCanvas3D::on_mouse(wxMouseEvent& evt)
     if (evt.Entering()) {
         // Set focus in order to remove it from sidebar fields and ensure hotkeys work
         if (m_canvas != nullptr) {
-            // Only set focus if the top level window of this canvas is active.
-            auto p = dynamic_cast<wxWindow*>(evt.GetEventObject());
-            while (p->GetParent())
-                p = p->GetParent();
-            auto *top_level_wnd = dynamic_cast<wxTopLevelWindow*>(p);
-            //Orca: Set focus so hotkeys like 'tab' work when a notification is shown.
-            if (top_level_wnd != nullptr && top_level_wnd->IsActive())
-                m_canvas->SetFocus();
+#if defined(__WXMSW__) && wxUSE_POPUPWIN
+            // Don't steal focus when a popup window is active (e.g., search dropdown).
+            // Stealing focus triggers MSWDismissUnfocusedPopup, closing the popup unexpectedly.
+            if (!wxCurrentPopupWindow)
+#endif
+            {
+                // Only set focus if the top level window of this canvas is active.
+                auto p = dynamic_cast<wxWindow*>(evt.GetEventObject());
+                while (p->GetParent())
+                    p = p->GetParent();
+                auto *top_level_wnd = dynamic_cast<wxTopLevelWindow*>(p);
+                //Orca: Set focus so hotkeys like 'tab' work when a notification is shown.
+                if (top_level_wnd != nullptr && top_level_wnd->IsActive())
+                    m_canvas->SetFocus();
+            }
             m_mouse.position = pos.cast<double>();
             m_tooltip_enabled = false;
             // 1) forces a frame render to ensure that m_hover_volume_idxs is updated even when the user right clicks while