diff --git a/src/slic3r/GUI/GUI_App.cpp b/src/slic3r/GUI/GUI_App.cpp
index 9056aba1d4..f719d01620 100644
--- a/src/slic3r/GUI/GUI_App.cpp
+++ b/src/slic3r/GUI/GUI_App.cpp
@@ -9114,6 +9114,10 @@ static bool del_win_registry(HKEY hkeyHive, const wchar_t *pszVar, const wchar_t
 void GUI_App::associate_files(std::wstring extend)
 {
 #ifdef WIN32
+    // MSIX: shell integration is declared in the package manifest; registry
+    // writes from a packaged process are virtualized and invisible to the shell.
+    if (is_running_in_msix())
+        return;
     wchar_t app_path[MAX_PATH];
     ::GetModuleFileNameW(nullptr, app_path, sizeof(app_path));
 
@@ -9139,6 +9143,8 @@ void GUI_App::associate_files(std::wstring extend)
 void GUI_App::disassociate_files(std::wstring extend)
 {
 #ifdef WIN32
+    if (is_running_in_msix())
+        return;
     wchar_t app_path[MAX_PATH];
     ::GetModuleFileNameW(nullptr, app_path, sizeof(app_path));
 
@@ -9190,6 +9196,8 @@ bool GUI_App::check_url_association(std::wstring url_prefix, std::wstring& reg_b
 void GUI_App::associate_url(std::wstring url_prefix)
 {
 #ifdef WIN32
+    if (is_running_in_msix())
+        return;
     boost::filesystem::path binary_path(boost::filesystem::canonical(boost::dll::program_location()));
     wxString wbinary = from_path(binary_path);
     BOOST_LOG_TRIVIAL(info) << "Downloader registration: Path of binary: " << wbinary.ToUTF8().data();
@@ -9215,6 +9223,8 @@ void GUI_App::associate_url(std::wstring url_prefix)
 void GUI_App::disassociate_url(std::wstring url_prefix)
 {
 #ifdef WIN32
+    if (is_running_in_msix())
+        return;
     wxRegKey key_full(wxRegKey::HKCU, "Software\\Classes\\" + url_prefix + "\\shell\\open\\command");
     if (!key_full.Exists()) {
         return;
diff --git a/src/slic3r/GUI/Preferences.cpp b/src/slic3r/GUI/Preferences.cpp
index 1e6b1f6558..dc502a55a9 100644
--- a/src/slic3r/GUI/Preferences.cpp
+++ b/src/slic3r/GUI/Preferences.cpp
@@ -1846,6 +1846,9 @@ void PreferencesDialog::create_items()
     //// ASSOCIATE TAB 
     /////////////////////////////////////
 #ifdef _WIN32
+    // MSIX: associations are declared in the package manifest and defaults are
+    // managed by Windows Settings; the runtime registry toggles below cannot work.
+    if (!is_running_in_msix()) {
     m_pref_tabs->AppendItem(_L("Associate"));
     f_sizers.push_back(new wxFlexGridSizer(1, 1, v_gap, 0));
     g_sizer = f_sizers.back();
@@ -1880,6 +1883,7 @@ void PreferencesDialog::create_items()
 
     g_sizer->AddSpacer(FromDIP(10));
     sizer_page->Add(g_sizer, 0, wxEXPAND);
+    }
 #endif // _WIN32
 
     //////////////////////////